Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
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Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
When using low quality samples, PCR-generated errors such as allelic drop-out and false alleles occur and have long perplexed researchers. In this issue of Science China, He et al. report the development of a mathematical model that treats homozygote and heterozygote separately to measure sample quality and to compute the confidence level of using multiple-tube approaches. This enables researchers to optimize experimental protocol through pilot studies and obtain reliable genetic information usi
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