Symposier - Mechanism of Resistance to Oseltamivir

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Symposier - Mechanism of Resistance to Oseltamivir

symposier.com

Uploaded and Shared in Youtube by: NEJMvideo The neuraminidase active site changes shape to create a pocket for oseltamivir, whereas it accommodates zanamivir without such a change. Any of several mutations may prevent the binding of oseltamivir by preventing the formation of this pocket; the oseltamivir-resistant virus can nonetheless bind to the host-cell sialic acid receptor and to zanamivir. The pocket for oseltamivir is created by the rotation of E276 and bonding of the amino acid to R224 "

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Tags: Flu Medication, Tamiflu, Relenza

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