Regulation of Cisplatin Cytotoxicity by Cu Influx Transporters
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Regulation of Cisplatin Cytotoxicity by Cu Influx Transporters
Platinum drugs are an important class of cancer chemotherapeutics. However, the use of these drugs is limited by the development of resistance during treatment with decreased accumulation being a common mechanism. Both Cu transporters CTR1 and CTR2 influence the uptake and cytotoxicity of cisplatin. Although it is structurally similar to CTR1, CTR2 functions in a manner opposite to that of CTR1 with respect to Pt drug uptake. Whereas knockout of CTR1 reduces Pt drug uptake, knockdown of CTR2 enh
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Regulation of Cisplatin Cytotoxicity by Cu Influx Transporters: Platinum drugs are an important class of cancer ... http://bit.ly/hAP8dN
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