Protein Involved in DNA Replication & Centrosome Regulation Linked to Dwarfism Small Brain Size | Neuroscience News

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Protein Involved in DNA Replication & Centrosome Regulation Linked to Dwarfism Small Brain Size | Neuroscience News

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Research just published by scientists at Cold Spring Harbor Laboratory (CSHL) links gene mutations found in some patients with Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are thought to give rise to a particularly extreme version of dwarfism, small brain size, and other manifestations of abnormal growth which generally characterize that rare condition.

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Protein Involved in DNA Replication, Centrosome Regulation Linked to Dwarfism, Small Brain Size http://t.co/MTldCGqE

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Detector of DNA damage: Structure of a repair factor revealed http://t.co/fDY1qWod

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Detector of DNA damage: Structure of a repair factor revealed

medicalxpress.com — “Double-stranded breaks in cellular DNA can trigger tumorigenesis. Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich, Germany, have determined the structure of a protein involved in the repair and signaling of DNA double-strand breaks. The work throws new light on the origins of neurodegenerative ...View full resource at medicalxpress.com

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Detector of DNA damage: Structure of a repair factor revealed http://t.co/KB3uHhlw

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DNA replication protein also has a role in mitosis, cancer - National Cancer Institute

cancer.gov — “The foundation of biological inheritance is DNA replication – a tightly coordinated process in which DNA is simultaneously copied at hundreds of thousands of different sites across the genome. If that copying mechanism doesn’t work as it should, the resulView full resource at cancer.gov

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Researchers at UNC (home of @UNC_Lineberger) find DNA replication protein also has a role in mitosis & #cancer http://t.co/NBf3Ziiw

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news.unchealthcare.org — “The finding presents a possible explanation for why so many cancers possess not just genomic instability, but also more or less than the usual 46 DNA-containing chromosomes.View full resource at news.unchealthcare.org

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Protein researchers unravel the molecular dance of DNA repair

physorg.com — “Using state-of-the-art technology, scientists at the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen and their international collaborators have successfully obtained 'molecular snapshots' of tens of thousands processes involved in DNA damage repair. On a daily basis ...View full resource at physorg.com

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Protein researchers unravel the molecular dance of DNA repair http://t.co/W2IhoDhd

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Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions - Uno - 2011 - Genes to Cells - Wiley Online Library

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sciencedaily.com — “A new study shows how inflammation can help cause cancer. The study found that inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155). This increase, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can contribute to cancer development. The findings suggest that drugs designed to reduce miR-155 levels might improve the treatment of inflammation-related cancers.View full resource at sciencedaily.com

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Researchers discover key protein involved in DNA repair

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Researchers discover key protein involved in DNA repair: In a groundbreaking study, University of Toronto research... http://bit.ly/c6uZCO

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physorg.com — “In a groundbreaking study, University of Toronto researchers including Professors Daniel Durocher, Anne-Claude Gingras and Frank Sicheri have uncovered a protein called OTUB1 that blocks DNA damage in the cell -- a discovery that may lead to the development of strategies to improve some cancer therapies.View full resource at physorg.com

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physorg.com — “A team of investigators led by a physician-scientist at The University of Texas MD Anderson Cancer Center has shown for the first time that the small protein SUMO can team up with the replication protein A (RPA) complex to facilitate DNA repair. The study is published in the Aug. 13 edition of the journal ...View full resource at physorg.com

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