Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats

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Promotion of the Toxic Action of Cyclophosphamide by Digestive Tract Luminal Ammonia in Rats

hindawi.com

To estimate the influence of the digestive tract luminal ammonia pool on acute toxic effects of cyclophosphamide, the dynamics of blood ammonia, glutamine and urea level, symptoms of toxic action and the survival time have been studied in rats, intraperitoneally treated with cyclophosphamide, at the background of the gavage with non-lethal dose of ammonium acetate (12?mmol/kg, i.e., 0.35 LD50). Ammonium acetate enhanced the hyperammonaemic action of cyclophosphamide while promoting its lethal ac

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Tags: Poison, Digestion

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