Orphanet Journal of Rare Diseases | Abstract | Genome-Wide Association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
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Orphanet Journal of Rare Diseases | Abstract | Genome-Wide Association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
ojrd.com —
Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described. Objectives: To investigate genetic association at a genome-wide level on a large sample of SJS/TEN patients. Methods: We performed a genome wide association study on a sample of 424 European cases and 1,881 controls selected from a Reference Control Panel. Results: Six SNPs located in the HLA regi
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Tags: Skin, Poison, Genetic, Disease and Condition, Drug, disease
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