NHS Evidence - Gastroenterology and liver diseases - Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices

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NHS Evidence - Gastroenterology and liver diseases - Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices

Bottom-line conclusion:Isosorbide-mononitrate used alone or in combination with beta blockers does not seem to offer any reduction in bleeding in the primary or secondary prevention of oesophageal varices. Compared with endoscopic therapy, there may be a survival advantage in using isosorbide-mononitrate (IsMn) and beta-blockers, but additional large multicentre trials are needed to verify this finding. Background and aims:The evidence concerning the use of IsMn for oesophageal varices is equivo

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Tags: Bleeding, Gastroenterology, Liver, Liver Condition, Disease and Condition, Beta Blocker, disease