New Breast Cancer Tumor Suppressor Identified

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New Breast Cancer Tumor Suppressor Identified

medicalnewstoday.com

Researchers have identified a protein long known to regulate gene expression as a potent suppressor of breast cancer growth. Their study, in the journal Oncogene, is the first to demonstrat

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Tags: Cancer, Breast Cancer, Protein, Genes, Women's Health

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Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests

sciencedaily.com — “A leaky gut may be the root of some cancers forming in the rest of the body, a new study suggests. It appears that the hormone receptor guanylyl cyclase C (GC-C) -- a previously identified tumor suppressor that exists in the intestinal tract -- plays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. Without the receptor, that barrier weakens.View full resource at sciencedaily.com

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Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 : Nature Medicine : Nature Publishing Group

nature.com — “BRCA1 loss of function is considered to promote tumorigenesis through impairment of the protein's role in DNA damage repair. By studying BRCA1 mutations that do not affect this function but still confer cancer predisposition, this report identifies a new function of BRCA1, the repression of miR-155 through modulation of HDAC activity. miR-155 increase correlates with BRCA1 loss or mutation in humans, and it likely to mediate some of the oncogenic effects of BRCA1 deficiency.View full resource at nature.com

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Study shows relationship between 2 mutated genes can dictate outcome of prostate cancer

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Key metabolic pathway implicated in intractable form of breast cancer

sciencedaily.com — “Using a new in vivo screening system, researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)-negative breast cancer. When the expression of the gene that codes for this protein -- phosphoglycerate dehydrogenase or PHGDH -- is suppressed in tumors and cell lines with an overabundance of the protein, the rate of cellular growth declines markedly. PHGDH is overexpressed in approximately 70 percent of ER-negative breast cancer patients.View full resource at sciencedaily.com

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Key metabolic pathway implicated in intractable form of breast cancer

sciencedaily.com — “Using a new in vivo screening system, researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)-negative breast cancer. When the expression of the gene that codes for this protein -- phosphoglycerate dehydrogenase or PHGDH -- is suppressed in tumors and cell lines with an overabundance of the protein, the rate of cellular growth declines markedly. PHGDH is overexpressed in approximately 70 percent of ER-negative breast cancer patients.View full resource at sciencedaily.com

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Key metabolic pathway implicated in intractable form of breast cancer

sciencedaily.com — “Using a new in vivo screening system, researchers have identified a protein in a key metabolic pathway that is essential in estrogen receptor (ER)-negative breast cancer. When the expression of the gene that codes for this protein -- phosphoglycerate dehydrogenase or PHGDH -- is suppressed in tumors and cell lines with an overabundance of the protein, the rate of cellular growth declines markedly. PHGDH is overexpressed in approximately 70 percent of ER-negative breast cancer patients.View full resource at sciencedaily.com

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Potent Breast Cancer Tumor Suppressor Identified

medicalnewstoday.com — “Researchers have identified the gene-regulating protein Runx3 as a potent suppressor of tumor growth in breast cancer and found that it most likely does this by regulating cellular response to cView full resource at medicalnewstoday.com

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Team identifies new breast cancer tumor suppressor and how it works

eurekalert.org — “Researchers have identified a protein long known to regulate gene expression as a potent suppressor of breast cancer growth. Their study, in the journal Oncogene, is the first to demonstrate how this protein, known as Runx3, accomplishes this feat.View full resource at eurekalert.org

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Most Recently Shared on June 27, 2011 at 9:58 pm By:

Signaling Pathways Point to Vulnerability in Breast Cancer Stem Cells - ScienceNewsline

sciencenewsline.com — “CAMBRIDGE, Mass. (June 9, 2011) – Whitehead Institute researchers have identified signals from breast epithelial cells that can induce those cells to transition to and maintain a mesenchymal and stem cell-like cell state that imbues both normal and cancer cells with a greater ability to migrate and self-renew. Interrupting these signals strips the cells of the migratory, invasive and self-renewal abilities used by cancer stem cells to seed new tumors.View full resource at sciencenewsline.com

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Medical News: FDA Clears Improved HER2 Test in Breast Cancer - in Oncology/Hematology, Breast Cancer from MedPage Today

medpagetoday.com — “The FDA has approved a new quantitative test for HER2 genes in breast tumor samples that can be performed under a standard microscope, potentially making it easier to identify patients who would benefView full resource at medpagetoday.com

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Signaling Pathways Point to Vulnerability in Breast Cancer Stem Cells

newswise.com — “Whitehead Institute researchers have identified signals impinging on breast epithelial cells that can induce those cells to acquire and stably display migratory and self-renewing characteristics. Interrupting these and other extracellular signals strips the various types of stem cells of the migratory and self-renewal abilities used by cancer stem cells to seed new tumors.View full resource at newswise.com

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