Recommended Pages at nature.com
Annotating MYC status with 89Zr-transferrin imaging : Nature Medicine : Nature Publishing Group
nature.com — “By exploiting the relationship between the transcription factor MYC and the transferrin receptor, where the level of transferrin receptor 1 expression may indicate activation of the MYC oncogenic pathway, Jason Holland and his colleagues have developed a novel PET radiotracer to quantitatively and noninvasively measure MYC activity. The 89Zr-desferrioxamine transferrin PET radiotracer was tested in several murine models of inflammation and MYC-driven prostate cancer.” View full resource at nature.com
Most Recently Shared on September 24, 2012 at 3:56 pm By:
Nature Medicine Science Enthusiast
A team from @sloan_kettering has developed a PET radiotracer for quantitatively & noninvasively measuring MYC activity: http://t.co/DZrDBRXX
LIFR identified as a breast cancer metastasis suppressor; its loss promotes metastasis but not primary tumor growth. http://t.co/OjS2JJn7
nature.com — “LIFR identified as a breast cancer metastasis suppressor; its loss promotes metastasis but not primary tumor growth. http://t.co/OjS2JJn7” View full resource at nature.com
Most Recently Shared on September 24, 2012 at 3:52 pm By:
Nature Medicine Science Enthusiast
LIFR identified as a breast cancer metastasis suppressor; its loss promotes metastasis but not primary tumor growth. http://t.co/OjS2JJn7
Synthetic biology in a vertebrate: Custom gene edits rewrite zebrafish DNA. NATURE http://t.co/1FjCGW5W http://t.co/iXwKnlbW #PM101 #SYNBIO
nature.com — “Synthetic biology in a vertebrate: Custom gene edits rewrite zebrafish DNA. NATURE http://t.co/1FjCGW5W http://t.co/iXwKnlbW #PM101 #SYNBIO” View full resource at nature.com
Most Recently Shared on September 24, 2012 at 2:49 pm By:
westr PhD, Doctor, and Health Social Media
Synthetic biology in a vertebrate: Custom gene edits rewrite zebrafish DNA. NATURE http://t.co/1FjCGW5W http://t.co/iXwKnlbW #PM101 #SYNBIO
Endothelial PI3K-C2[alpha], a class II PI3K, has an essential role in angiogenesis and vascular barrier function : Nature Medicine : Nature Publishing Group
nature.com — “Although type I phosphatidylinositol 3-kinases (PI3Ks) are well studied signaling proteins, the functions of other PI3Ks are more enigmatic. Kazuaki Yoshioka et al. find that the type II PI3K-2[alpha] isoform regulates endosomal trafficking and cell signaling in endothelial cells. Angiogenic and vascular permeability responses are attenuated in mice lacking PI3K-2[alpha], pointing to this enzyme as a potential target for treating vascular disease.” View full resource at nature.com
Most Recently Shared on September 17, 2012 at 3:17 pm By:
Nature Medicine Science Enthusiast
PI3K-2α: a potential new target for treating vascular disease: http://t.co/0An451ac
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers : Nature Medicine : Nature Publishing Group
nature.com — “A limitation of photodynamic therapy (PDT) is the depth of penetration of visible light needed for activation of the photosensitizers, restricting treatment to tumors on or just under the skin’s surface or those lining internal organs and cavities. Niagara Muhammad Idris and colleagues have addressed this issue by developing upconversion fluorescent nanoparticles (UNCs) that convert deeper penetrating near-infrared light to visible wavelengths without sacrificing efficacy for singlet oxygen (1O2” View full resource at nature.com
Most Recently Shared on September 17, 2012 at 3:13 pm By:
Nature Medicine Science Enthusiast
In vivo photodynamic therapy using nanoparticles helps target melanoma tumor cells: http://t.co/nAnPNkf7
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma : Nature Medicine : Nature Publishing Group
nature.com — “NRAS-driven melanomas have limited therapeutic options. Combining genetically engineered models and oncogenic signaling inhibitors with rational systems-biology approaches, the authors compare the effects of genetic extinction of NRAS to that of chemical pathway inhibition targeting downstream MEK. The differences provide actionable targets by revealing that NRAS signaling operates as a gated output and that MEK inhibition, although inducing apoptosis, is not able to achieve further inhibition o” View full resource at nature.com
Most Recently Shared on September 17, 2012 at 3:10 pm By:
Nature Medicine Science Enthusiast
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma: http://t.co/Vn7ePQlo
2012 Albert Lasker Medical Research Awards : Nature Medicine
nature.com — “Nature Medicine is the premier journal for biomedical research. Respected internationally for the quality of its papers on areas ranging from infectious disease to cancer and neurodegeneration, Nature Medicine aims to bridge the gap between basic research and medical advances and is consistently ranked the number one journal by the Institute of Scientific Investigation in the Medicine, Research and Experimental category.” View full resource at nature.com
Most Recently Shared on September 11, 2012 at 2:35 pm By:
Nature Medicine Science Enthusiast
RT @natrevgastrohep: See this special on the #Lasker Medical Research Awards in @NatureMedicine http://t.co/YTZHPQGm
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines : Nature Medicine : Nature Publishing Group
nature.com — “Live attenuated SIV vaccines protect nonhuman primates from infection with pathogenic wild-type SIV, but the crucial mechanisms have not been clear. In this issue, Louis Picker and colleagues show that protection by live attenuated vaccines against intravenous SIV challenge in rhesus macaques is associated with SIV-specific T cell response in the lymph nodes, and not the blood, and persistent SIV replication in lymph node follicular T helper cells.” View full resource at nature.com
Most Recently Shared on September 11, 2012 at 2:18 pm By:
Nature Medicine Science Enthusiast
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines: http://t.co/ERewlx0o
Institutes experiment with a variety of different appeal processes : Nature Medicine : Nature Publishing Group
nature.com — “Institutes experiment with a variety of different appeal processes : Nature Medicine : Nature Publishing Group” View full resource at nature.com
Most Recently Shared on September 11, 2012 at 2:10 pm By:
Nature Medicine Science Enthusiast
Institutes and funding agencies experiment with a variety of different appeal processes: http://t.co/jRiYcBvc (by @rpalmerscience)
Drug companies look to biomarkers to salvage cancer target : Nature Medicine : Nature Publishing Group
nature.com — “Drug companies look to biomarkers to salvage cancer target : Nature Medicine : Nature Publishing Group” View full resource at nature.com
Most Recently Shared on September 11, 2012 at 12:40 pm By:
Nature Medicine Science Enthusiast
Drug companies look to biomarkers to salvage IGF1R cancer target: http://t.co/Xgdao40e
Exon-skipping drug pulls ahead in muscular dystrophy field : Nature Medicine : Nature Publishing Group
nature.com — “Exon-skipping drug pulls ahead in muscular dystrophy field : Nature Medicine : Nature Publishing Group” View full resource at nature.com
Most Recently Shared on September 7, 2012 at 7:23 pm By:
Nature Medicine Science Enthusiast
Exon-skipping drug pulls ahead in muscular dystrophy field: http://t.co/aoHv6mNv (by @alisaopar)
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans : Nature Medicine : Nature Publishing Group
nature.com — “Epha4 is a receptor involved in axonal repulsion. Wim Robberecht and his colleagues report that genetic or pharmacological inhibition of Epha4 is protective in rodent and zebrafish models of amyotrophic lateral sclerosis. In humans, expression of Epha4 inversely correlates with disease onset and survival, and in two patients, mutations in Epha4 are associated with longer survival, suggesting Epha4 may be targeted therapeutically to prevent axonal degeneration.” View full resource at nature.com
Most Recently Shared on August 26, 2012 at 7:18 pm By:
westr PhD, Doctor, and Health Social Media
RT @NatureMedicine: Scientists identify a new gene that affects survival in animals and humans with ALS: http://t.co/lU3kdqAw #pm101
Nutritional deficiencies after bariatric surgery : Abstract : Nature Reviews Endocrinology
nature.com — “Nutritional deficiencies after bariatric surgery : Abstract : Nature Reviews Endocrinology” View full resource at nature.com
Most Recently Shared on August 20, 2012 at 3:19 pm By:
Moises Auron MD Internist, Physician, Doctor, and Pediatrician
Nutritional deficiencies after bariatric surgery. http://t.co/wxAP6FAX
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder : Nature Medicine : Nature Publishing Group
nature.com — “Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of the transcriptional repressor, GATA1. Expression of GATA1 in prefrontal cortex neurons decreases the expression of synapse-related genes, reduces dendrite branching and produces depressive behavior in a rat model of depression.” View full resource at nature.com
Most Recently Shared on August 13, 2012 at 12:37 pm By:
Nature Medicine Science Enthusiast
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder: http://t.co/g619TKPV
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells : Nature Genetics : Nature Publishing Group
nature.com — “Shaoguang Li and colleagues show that the Blk pathway functions as a tumor suppressor in cancer stem cells of chronic myeloid leukemia but has no effect on normal hematopoietic stem cells. These results support the feasibility of selectively targeting leukemic stem cells without harming the normal stem cell compartment.” View full resource at nature.com
Most Recently Shared on July 19, 2012 at 4:21 pm By:
Jan Cerny, MD, PhD PhD, Internist, Oncologist, Hematologist, Physician, and Doctor
Scientists @umassmemorial @UMassMedNow discover new leukemic stem cell (#LSC) pathway in chronic myeloid leukemia #CML http://t.co/k8oDtOH1
