Mutations to the rescue : Nature Medicine : Nature Publishing Group
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Mutations to the rescue : Nature Medicine : Nature Publishing Group
View full resource at nature.com
Tags: Skin, Genetic, Disease and Condition, Genes, disease, Nature, Medical
Most Recently Shared on April 8, 2011 at 1:38 pm By:
Nice discussion of YSM work on ichthyosis with confetti in "natural gene therapy" piece in @naturemedicine http://bit.ly/giQqHs
Straight talk with... Robert Beall : Nature Medicine : Nature Publishing Group
nature.com — “When Robert J. Beall joined the Cystic Fibrosis Foundation in 1980, he launched a program aimed at absorbing the early financial risk involved in drug development as a way to entice for-profit companies to get involved in cystic fibrosis research. That strategy was vindicated with the approval in January of the first small-molecule drug that directly interacts with the mutated protein responsible for cystic fibrosis. Elie Dolgin spoke with Beall to learn more about his organization’s pioneering ” View full resource at nature.com
Most Recently Shared on March 7, 2012 at 5:13 pm By:
Nature Medicine Science Enthusiast
After success of Kalydeco, Robert Beall of @cf_foundation discusses his approach to venture philanthropy: http://t.co/0M0wMvsX
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies : Nature Medicine : Nature Publishing Group
nature.com — “Using high-coverage targeted next-generation sequencing, this report provides a catalog of genetic alterations in colorectal and lung cancers, identifying previously unknown alterations, such as JAK2 mutations and KIF5B-RET fusions, that may represent druggable targets.” View full resource at nature.com
Most Recently Shared on February 13, 2012 at 9:11 pm By:
westr Health Social Media, PhD, and Doctor
Foundation Medicine: Cancer Dx IDs Clinically Actionable Mutations NATURE MEDICINE http://t.co/6zQvqt4Q & http://t.co/wScoQrkK 145 genes NGS
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 : Nature Medicine : Nature Publishing Group
nature.com — “BRCA1 loss of function is considered to promote tumorigenesis through impairment of the protein's role in DNA damage repair. By studying BRCA1 mutations that do not affect this function but still confer cancer predisposition, this report identifies a new function of BRCA1, the repression of miR-155 through modulation of HDAC activity. miR-155 increase correlates with BRCA1 loss or mutation in humans, and it likely to mediate some of the oncogenic effects of BRCA1 deficiency.” View full resource at nature.com
Most Recently Shared on September 26, 2011 at 5:23 pm By:
NCI Cancer Bulletin Health News
Study identifies a new function of BRCA1 http://j.mp/pUecHd (abstract) #breastcancer #microRNA
Inhibitory neurons key to understanding neuropsychiatric disorders
eurekalert.org — “In 1999, Baylor College of Medicine researcher Dr. Huda Zoghbi, and her colleagues identified mutations in one of these genes called MECP2 as the culprit in a devastating neurological disorder called Rett syndrome. In new research in mice published in the current issue of the journal Nature, Zoghbi and her colleagues demonstrate that the loss of the protein MeCP2 in a special group of inhibitory nerve cells in the brain reproduces nearly all Rett syndrome features.” View full resource at eurekalert.org
Most Recently Shared on November 10, 2010 at 7:50 pm By:
Jonathan Reed Doctor and Psychologist
RT @Neuro_science: Inhibitory neurons key to understanding neuropsychiatric disorders - EurekAlert (press release) http://bit.ly/9bcY8v
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