Landes Bioscience Journals: Cancer Biology & Therapy

Links shared publicly online about this topic.

169
total visits

Landes Bioscience Journals: Cancer Biology & Therapy

Although treatments have improved patient prognosis in surgically resectable colorectal cancer, new effective drugs with improved safety profiles are needed to improve the currently poor outcomes of patients with recurrent or metastatic colorectal cancer. Quinacrine, a small molecule anti-malarial agent that has activity in giardiasis, lupus, prion disease, and used as a means of non-surgical sterilization, has shown cytotoxic activity across a broad range of cancers. Here, we evaluate the poten

View full resource at landesbioscience.com

Tags: Cancer, Rectal Cancer, Colon Cancer, Colorectal Cancer Medication, 5-FU, Adrucil, Efudex

Most Recently Shared on July 5, 2011 at 10:23 am By:

Wafik El-Deiry MD, PhD

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer http://t.co/6q96hPK

11 months ago...

Retweet

Favorite

Landes Bioscience Journals: Cancer Biology & Therapy

landesbioscience.com — “Quinacrine has been widely explored in treatment of malaria, giardiasis, and rheumatic diseases. We find that quinacrine stabilizes p53 and induces p53-dependent and independent cell death. Treatment by quinacrine alone at concentrations of 10–20 mM for 1–2 d cannot kill hepatocellular carcinoma cells, such as HepG2, Hep3B, Huh7, which are also resistant to TRAIL. However, quinacrine renders these cells sensitive to treatment by TRAIL. Co-treatment of these cells with quinacrine and TRAIL induce” View full resource at landesbioscience.com