Landes Bioscience Journals: Cancer Biology & Therapy
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Landes Bioscience Journals: Cancer Biology & Therapy
Quinacrine has been widely explored in treatment of malaria, giardiasis, and rheumatic diseases. We find that quinacrine stabilizes p53 and induces p53-dependent and independent cell death. Treatment by quinacrine alone at concentrations of 10–20 mM for 1–2 d cannot kill hepatocellular carcinoma cells, such as HepG2, Hep3B, Huh7, which are also resistant to TRAIL. However, quinacrine renders these cells sensitive to treatment by TRAIL. Co-treatment of these cells with quinacrine and TRAIL induce
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Inexpensive antimalarial drug Quinacrine has potential as therapeutic in colorectal & liver cancer http://t.co/6q96hPK & http://t.co/uejpj9f
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