Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool : Nature Neuroscience : Nature Publishing Group

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Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool : Nature Neuroscience : Nature Publishing Group

The authors examine the roles of microglia and blood-derived macrophages (which are morphologically indistinguishable) in experimental autoimmune encephalitis, a mouse model of multiple sclerosis. They discover that the transient infiltration of circulating cells is responsible for progression to paralytic disease, and that disease resolution coincides with their disappearance.

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Tags: Encephalitis, Multiple Sclerosis, Paralysis, disease, Nature, Neuroscience