Inadvertent reprogramming of genes in peripheral nervous system may cause chronic pain

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Inadvertent reprogramming of genes in peripheral nervous system may cause chronic pain

Chronic pain severely limits patients' quality of life and is among the cost drivers in U.S. health care. Patients can suffer pain without an apparent cause and often fail to respond to available treatments. Mayo Clinic researchers and collaborators now report that chronic pain may be caused by the inadvertent reprogramming of more than 2,000 genes in the peripheral nervous system. The research findings appear in the current issue of the journal Genome Research.

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Tags: Nervous System, Pain, Chronic Pain, Stroke, Thrombotic Event, Healthcare, Genes

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Candidate gene culprits for chronic pain discovered

sciencedaily.com — “Scientists report that chronic pain may be caused by the inadvertent reprogramming of more than 2,000 genes in the peripheral nervous system. The research might ultimately lead to "transcription therapy," the researchers speculate, which would employ drugs that kill pain by correcting the activity of specific genes.” View full resource at sciencedaily.com