IgA-Dominant Postinfectious Glomerulonephritis: A New Twist on an Old Disease

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IgA-Dominant Postinfectious Glomerulonephritis: A New Twist on an Old Disease

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is an increasingly recognized morphologic variant of APIGN, particularly in the elderly. In contrast to classic APIGN, in which there is typically glomerular deposition of IgG and C3 or C3 only, IgA is the sole or dominant immunoglobulin in IgA-dominant APIGN. Because the vast majority of reported cases occur in association with staphylococcal infections, the alternative designation ‘IgA-dominant acute poststaphylococcal glomerulonephr

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Tags: Infection, Kidney Health, Kidney Disease, Disease and Condition, Senior Health, Nephritis, disease