Glioblastoma multiforme in the Dock

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Glioblastoma multiforme in the Dock

eurekalert.org

Glioblastoma multiforme is the most common malignant brain cancer in humans. Patients with this highly aggressive form of cancer have a poor prognosis because it is commonly resistant to current therapies. Researchers have now identified a molecular pathway that drives the aggressive cancerous nature of a many glioblastomas; specifically, those that overexpress the protein PDGFR-alpha. This pathway could represent a novel and attractive therapeutic target for treating individuals with glioblasto

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Tags: Brain, Cancer, Brain Cancer, Brain Tumor, Protein, Nature

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BMC Cancer | Abstract | Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

biomedcentral.com — “The treatment of patients with malignant brain tumors remains a major oncological problem. The median survival of patients with glioblastoma multiforme (GBM), the most malignant type, is only 15 months after initial diagnosis and even less after tumor recurrence. Improvements of standard treatment including surgery and radio-chemotherapy have not lead to major improvements. Therefore, alternative therapeutics such as oncolytic viruses that specifically target and destroy cancer cells are under iView full resource at biomedcentral.com

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New potential therapeutic target for brain cancer - National Cancer Institute

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eurekalert.org — “Glioblastoma multiforme is the most common and lethal human brain tumor that originates in the brain. For most patients, treatment involves surgery followed by both radiation therapy and chemotherapy with temozolomide. However, many GBMs are resistant to the effects of temozolomide. Researchers have now gained new insights into the mechanisms contributing to temozolomide resistance that might help predict patient responsiveness to the drug.View full resource at eurekalert.org

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medicalnewstoday.com — “Researchers from Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have discovered a mechanism by which glioblastoma multiforme (GBM), the most commView full resource at medicalnewstoday.com

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