FDA alert on clopidogrel PPI

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FDA alert on clopidogrel PPI

theheart.org

The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction.

View full resource at theheart.org

Tags: GERD Medication, Zollinger-Ellison Syndrome Medication, FDA, Anti-Clotting Medication, Plavix, Iscover, Cardiologist, Cardiology

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Most Recently Shared on November 17, 2009 at 9:25 pm By:

theheartorg Shelley Wood

Cardiologists shocked by new FDA alert on clopidogrel-PPI interaction http://bit.ly/1c8h4X #SS09 #aha09

2 years ago...

FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor drugs (PPIs)

fda.gov — “[3-2-2011] The U.S. Food and Drug Administration (FDA) is informing the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year).View full resource at fda.gov

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Most Recently Shared on March 9, 2011 at 1:16 pm By:

NutritionNurse1 Suzanne Lugerner Nurse

FDA Alert: Proton Pump Inhibitors and Low Magnesium levels http://1.usa.gov/g8rGb9

1 year ago...

Long-Term Use of Proton-Pump Inhibitors May Lower Magnesium Levels - Physician's First Watch

firstwatch.jwatch.org — “Using a proton-pump inhibitor for extended periods may cause low serum magnesium levels, the FDA cautioned yesterday. The agency issued the alert after reviewing more than 50 cases of hypomagnesemia in patients taking PPIs over . . . LINK(S):View full resource at firstwatch.jwatch.org

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Most Recently Shared on March 5, 2011 at 3:05 am By:

phylili Lionel Lim Internist, Geriatrician, Physician, and Doctor

Long-Term PPI use Lowers Magnesium Levels - over long periods, usually a year or more. http://icio.us/U7X9ab

1 year ago...

Clopidogrel-PPI: Mechanistic studies | theheart.org theheart.org: Interventional and Surgery news and education

theheart.org — “Heartwire staff and renowned specialists in cardiology from Duke Clinical Research Institute and Mayo Clinic discuss latest developments in interventional surgery.View full resource at theheart.org

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Most Recently Shared on September 20, 2010 at 5:20 pm By:

theheartorg Shelley Wood Cardiology

Clopidogrel-PPI interaction: Mechanistic studies that led to FDA warning now published: But cardiologists continue... http://bit.ly/dsteR1

2 years ago...

ACC and AHA on clopidogrel label | theheart.org

theheart.org — “The ACC and AHA issued a clinical alert just 12 weeks after the FDA black-box warning on clopidogrel, stating that routine genetic or platelet-function testing is not recommended when using antiplatelet therapy. They do leave the door open a crack, however, and allow for such testing in patients believed to be at moderate or high risk for poor outcomes, to be used at the physician's discretion.View full resource at theheart.org

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Most Recently Shared on June 30, 2010 at 5:50 pm By:

theheartorg Shelley Wood Cardiology

No routine genetic or platelet-function testing for clopidogrel nonresponsiveness: ACC, AHA: The ACC and AHA issue... http://bit.ly/d8ujUf

2 years ago...

FDA Alert: Proton Pump Inhibitors (PPI): Class Labeling Change

drugs.com — “FDA Alert: Proton Pump Inhibitors (PPI): Class Labeling ChangeView full resource at drugs.com

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FDA Alert - Labeling Change for Proton Pump Inhibitors - http://bit.ly/cmqvjA

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FDA Announces New Boxed Warning On Plavix

medicalnewstoday.com — “The U.S. Food and Drug Administration added a boxed warning to the anti-blood clotting drug Plavix (clopidogrel), alerting patients and health care professionals that the drug can be less effectivView full resource at medicalnewstoday.com

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Most Recently Shared on March 15, 2010 at 2:06 pm By:

FDA warns patients and physicians about the efficacy of Plavix treatment

news-medical.net — “The U.S. Food and Drug Administration today added a boxed warning to the anti-blood clotting drug Plavix (clopidogrel), alerting patients and health care professionals that the drug can be less effective in people who cannot metabolize the drug to convert it to its active form.View full resource at news-medical.net

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Most Recently Shared on March 15, 2010 at 4:57 am By:

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FDA warns patients and physicians about the efficacy of Plavix treatment: The U.S. Food and Drug Administration to... http://bit.ly/byC3Vt

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drugs.com — “FDA Alert: Plavix (clopidogrel): Reduced effectiveness in patients who are poor metabolizers of the drugView full resource at drugs.com

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Most Recently Shared on March 14, 2010 at 12:55 am By:

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RT @drugscom FDA Alert: Plavix (clopidogrel): Reduced effectiveness in patients who are poor metabol.. http://is.gd/aoMTl

2 years ago...

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drugs.com — “The U.S. Food and Drug Administration today added a boxed warning to the anti-blood clotting drug Plavix (clopidogrel), alerting patients and health care profesView full resource at drugs.com

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Most Recently Shared on March 13, 2010 at 5:54 am By:

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FDA Announces New Boxed Warning on Plavix - http://bit.ly/cU7CJJ

2 years ago...

FDA Announces New Boxed Warning on Plavix

fda.gov — “The U.S. Food and Drug Administration today added a boxed warning to the anti-blood clotting drug Plavix (clopidogrel), alerting patients and health care professionals that the drug can be less effective in people who cannot metabolize the drug to convert it to its active form.View full resource at fda.gov

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Most Recently Shared on March 12, 2010 at 7:28 pm By:

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FDA's Bob Temple on new Plavix boxed warning: ''There's more uncertainty than I wish we had about what 2 do." http://bit.ly/asICPn #genetics

2 years ago...

FDA Alert: Clopidogrel (marketed as Plavix) and Omeprazole (marketed as Prilosec) - Drug Interaction

drugs.com — “FDA Alert: Clopidogrel (marketed as Plavix) and Omeprazole (marketed as Prilosec) - Drug InteractionView full resource at drugs.com

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Most Recently Shared on November 19, 2009 at 8:51 am By:

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FDA Alert - FDA Warns of Drug Interactions between Plavix and Prilosec - http://bit.ly/37OHXz

2 years ago...

FDA warns of drug interaction with clopidogrel and omeprazole - MPR

empr.com — “The FDA has notified healthcare professionals of new safety information concerning a drug interaction between clopidogrel bisulfate (Plavix, from Bristol-Myers Squibb and sanofi-aventis), a platelet aggregation inhibitor, and omeprazole (Prilosec, from AstraZeneca; and Prilosec OTC, from Procter & Gamble), a proton pump inhibitor (PPI).View full resource at empr.com

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Most Recently Shared on November 17, 2009 at 6:23 pm By:

eMPR MPR Medical Publisher

MPR News: FDA warns of drug interaction with clopidogrel and omeprazole: The FDA has notified healthcare profession... http://bit.ly/3MR012

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Medical News: FDA Approves New Antiplatelet for Angioplasty Patients - in Product Alert, Prescriptions from MedPage Today

medpagetoday.com — “WASHINGTON -- The FDA has approved the oral antiplatelet agent prasugrel (Effient), putting it in top running as a direct competitor for clopidogrel (Plavix).View full resource at medpagetoday.com

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Most Recently Shared on July 10, 2009 at 11:31 pm By:

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CARDIOLOGY• FDA Approves New Antiplatelet for Angioplasty Patients http://tinyurl.com/n4s9yg

3 years ago...

Clopidogrel-PPI interaction?

theheart.org — “The European Medicines Agency has now followed suit with the US FDA and issued a warning discouraging concomitant use of clopidogrel and PPIs, but some experts believe the issue has been overhyped.View full resource at theheart.org

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Most Recently Shared on June 19, 2009 at 6:26 pm By:

theheartorg Shelley Wood Cardiology

heartwire: EMEA issues warning on possible clopidogrel-PPI interaction, but is there really a problem? http://bit.ly/b9M2n

3 years ago...

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