Clinical and Translational Allergy | Abstract | Mechanisms of allergen-specific immunotherapy

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Clinical and Translational Allergy | Abstract | Mechanisms of allergen-specific immunotherapy

Allergen-specific immunotherapy (allergen-SIT) is a potentially curative treatment approach in allergic diseases. It has been used for almost 100 years as a desensitizing therapy. The induction of peripheral T cell tolerance and promotion of the formation of regulatory T-cells are key mechanisms in allergen-SIT. Both FOXP3+CD4+CD25+ regulatory T (Treg) cells and inducible IL-10- and TGF-beta-producing type 1 Treg (Tr1) cells may prevent the development of allergic diseases and play a role in suc

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Tags: Allergies, Disease and Condition, disease