Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

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Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines

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Tags: Obesity, Joint, Osteoarthritis, Disease and Condition, Fat, disease