A20 edits ubiquitin and autoimmune paradigms : Nature Genetics : Nature Publishing Group

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A20 edits ubiquitin and autoimmune paradigms : Nature Genetics : Nature Publishing Group

Complex autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, multiple sclerosis, psoriasis and inflammatory bowel disease have different pathological presentations but have overlapping genetic susceptibility variants. A new study using mice lacking Tnfaip3, whose ortholog is linked to autoimmune disease in humans, leads to insights in the role of one molecular driver of varied clinical symptomatology in disparate autoimmune disorders.

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Tags: Genetic, Autoimmune Disease, Arthritis, Rheumatoid Arthritis, Disease and Condition, disease, Nature, Genetics