Mammary Gland Tumor in Cats
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miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma : Nature Medicine : Nature Publishing Group
nature.com — “The characterization of miR-380-5p-driven p53 repression provides a new mechanism for downmodulation of stress-induced antiproliferative responses in wild-type p53 contexts, including embryonic stem cells and neuroblastoma tumors. miR-380-5p potentiates Ras-induced mammary gland tumorigenesis and is frequently elevated in human neuroblastomas. miR-380-5p inactivation induces tumor cell death and shows therapeutic efficacy in orthotopic neuroblastoma models.” View full resource at nature.com
Most Recently Shared on October 2, 2010 at 2:46 pm By:
Sandeep Pulim Doctor, Health Communicator, and Physician
miRNA: New mechanism of p53 regulation in cancer and stem cells. Potential therapeutic target for neuroblastoma. http://bit.ly/df88yy
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