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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder : Nature Medicine : Nature Publishing Group
nature.com — “Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of the transcriptional repressor, GATA1. Expression of GATA1 in prefrontal cortex neurons decreases the expression of synapse-related genes, reduces dendrite branching and produces depressive behavior in a rat model of depression.” View full resource at nature.com
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