Jon D. Moulton

Professional Information

Profession

Researcher / Scientist

Specialty/Area of Focus

Morpholino antisense

Other Specialty/Area of Focus

molecular biology

Bio

Work: Gene Tools, LLC (www.gene-tools.com): biology, chemistry. Interest: antisense technology for therapeutics and basic research. Also: environmental science, bicycles, China, camping, veggie gardening

Social Media and Site Links

 

http://blog.myspace.com/127542408
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Current Protocols Journal
Morpholino Publications Database
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Profile Details

Location

Philomath, Oregon, USA

Honorifics

PhD

Interests

Antisense

Skills

Chemistry

Biology

Languages

English (Native fluency)

Mandarin (Limited fluency)

Schools

Portland State University: 1990-1998 for doctoral studies
Ph.D.
Environmental Sciences and Resources: Biology
Activities and Societies: Sigma Xi, ASM

Publications

Morpholinos and Their Peptide Conjugates: Therapeutic promise and challenge for Duchenne muscular dystrophy.Biochim Biophys Acta. | 2010
Authors: Moulton HM, Moulton JD.

Compared to PMOs, far lower doses of PPMOs can restore dystrophin sufficiently to reduce disease pathology, increase skeletal and cardiac muscle functions, and prolong survival of animals. The biggest challenge for PPMO is determining safe and effective doses.

Gene Knockdowns in Adult Animals: PPMOs and Vivo-MorpholinosMolecules. | 2009
Authors: Moulton JD, Jiang S.

Antisense-based techniques such as blocking translation, modifying pre-mRNA splicing, inhibiting miRNA maturation and inhibiting viral replication can be conveniently applied in adult animals by injecting PPMOs or Vivo-Morpholinos.

Using morpholinos to control gene expression. Curr Protoc Mol Biol. | 2008
Authors: Moulton JD, Yan YL.

Morpholinos form stable base pairs with complementary nucleic acid sequences but apparently do not bind to proteins to a significant extent. They are not recognized by proteins and do not undergo protein-mediated catalysis; nor do they mediate RNA cleavage by RNase H or the RISC complex. This work focuses on techniques and background for using Morpholinos.

Antisense Morpholino Oligomers and Their Peptide Conjugates. In: Therapeutic OligonucleotidesRoyal Society of Chemistry | 2008
Authors: Moulton HM, Moulton JD.

Survey of therapeutic applications for Morpholinos

Site Groups

PhD, Active Health Library, Doctor, Science Enthusiast