Hyperlipoproteinemia Type II
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Endothelial PI3K-C2[alpha], a class II PI3K, has an essential role in angiogenesis and vascular barrier function : Nature Medicine : Nature Publishing Group
nature.com — “Although type I phosphatidylinositol 3-kinases (PI3Ks) are well studied signaling proteins, the functions of other PI3Ks are more enigmatic. Kazuaki Yoshioka et al. find that the type II PI3K-2[alpha] isoform regulates endosomal trafficking and cell signaling in endothelial cells. Angiogenic and vascular permeability responses are attenuated in mice lacking PI3K-2[alpha], pointing to this enzyme as a potential target for treating vascular disease.” View full resource at nature.com
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