Depression and alcohol abuse often go together: Up to 50% of people with alcoholism may have major depression and about 20% of people with depression may drink too much, too often. Genetics is part of the explanation: A family history of either problem increases your own risk. And research shows that drinking to feel good can be a powerful draw when you’re stuck in the black hole of depression. But self-medicating with beer, wine or spirits backfires. The cheery effects fade as alcohol reduces levels of feel-good brain chemicals serotonin and norepinephrine, leading to an even lower mood. If you use alcohol to overcome the insomnia common in depression, your sleep may be disrupted, too.

• Depression makes staying sober more difficult if you’re struggling with alcoholism. In one study, it raised risk for a return to drinking by 50%.
• Don’t drink if you take antidepressants called monoamine oxidase inhibitors. The combo can boost blood pressure, causing a stroke.
• Avoid alcohol with other antidepressants, too. You may feel more intoxicated or more drowsy than usual.
• In one study, people with depression and alcoholism who regularly attended Alcoholics Anonymous meetings saw depression ease significantly.
• In one study, young women with depression at age 27 were at high risk for alcohol problems by age 30.

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