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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder : Nature Medicine : Nature Publishing Group
nature.com — “Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of the transcriptional repressor, GATA1. Expression of GATA1 in prefrontal cortex neurons decreases the expression of synapse-related genes, reduces dendrite branching and produces depressive behavior in a rat model of depression.” View full resource at nature.com
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Nature Medicine is a biomedical research journal devoted to publishing the latest advances in biomedical research for scientists and physicians.
Peter Brown is a Clinical Psychologist with a private practice and consultancy in Brisbane, Australia. He has 20 years of experience in child, adult and family psychology. He is the co-founder of Christian Wholeness Counselling Services and enjoys researching issues of the brain & mind, reading and seeking out new books and resources for himself and his clients.