Clopidogrel
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FDA and clopidogrel
theheart.org — “The Food and Drug Administration is continuing to study the effectiveness of clopidogrel in patients taking other medications, particularly proton-pump inhibitors, and in those with genetic variants linked with clopidogrel resistance and a subsequent increased risk of cardiovascular outcomes.” View full resource at theheart.org
Most Recently Shared on January 26, 2009 at 10:30 pm By:
FDA continuing to study effectiveness of clopidogrel http://tinyurl.com/d4vdha
PPIs and clopidogrel
theheart.org — “The use of omeprazole significantly reduced the antiplatelet activity of clopidogrel, even with a high maintenance dose of the drug, and other PPIs, such as pantoprazole, should be preferred in clopidogrel-treated patients, according to investigators.” View full resource at theheart.org
Most Recently Shared on September 15, 2009 at 3:54 pm By:
heartwire: Omeprazole, but not pantoprazole, inhibits clopidogrel's platelet response http://bit.ly/h5vsd
Clopidogrel and PPIs
theheart.org — “Among discharged ACS patients prescribed the two drugs, there was a 25% increased risk of adverse clinical outcomes compared with those taking clopidogrel alone. (Ho PM et al. JAMA 2009; 301:937-944.)” View full resource at theheart.org
Most Recently Shared on March 3, 2009 at 9:36 pm By:
More data support adverse clopidogrel and proton-pump inhibitor interaction http://tinyurl.com/cqydb3
Clopidogrel and PPIs
theheart.org — “UPDATED WITH COMMENTARY // The findings support suspicions that the drug combination diminishes the beneficial effect of the antiplatelet therapy and increases the risk of future events, say researchers. (Juurlink DN et al. CMAJ; published online before print January 28, 2009.)” View full resource at theheart.org
Most Recently Shared on January 29, 2009 at 11:01 pm By:
Increased risk of reinfarction with clopidogrel and proton-pump inhibitors http://tinyurl.com/b7mrkd
Clopidogrel on #MDlinx
mdlinx.com — “Clopidogrel on #MDlinx” View full resource at mdlinx.com
Most Recently Shared on October 18, 2010 at 7:36 pm By:
Sandeep Pulim MD Doctor, Health Communicator, and Physician
Allergic Reactions to Clopidogrel and Cross-Reactivity to Other Agents: Current Allergy and Asthma Reports http://bit.ly/9tq4s7 #Allergy
Clopidogrel Pharmacogenomics
blogs.theheart.org — “Clopidogrel Pharmacogenomics” View full resource at blogs.theheart.org
Most Recently Shared on January 14, 2009 at 1:31 am By:
Dr Walton-Shirley Physician, Doctor, Internist, and Cardiologist
From theheart.org bl Clopidogrel Pharmacogenomics: 3 new studies, 2 in the New England J of .. http://tinyurl.com/7f3nz6
Coumarin/clopidogrel interaction?
theheart.org — “Another interaction that may affect the response to clopidogrel has been reported, this time with the coumarin derivative phenprocoumon, an anticoagulant commonly used in Europe.” View full resource at theheart.org
Most Recently Shared on September 17, 2009 at 4:24 pm By:
heartwire: Coumarin derivatives affect clopidogrel action http://bit.ly/jq384
Clopidogrel-PPI interaction?
theheart.org — “The European Medicines Agency has now followed suit with the US FDA and issued a warning discouraging concomitant use of clopidogrel and PPIs, but some experts believe the issue has been overhyped.” View full resource at theheart.org
Most Recently Shared on June 19, 2009 at 6:26 pm By:
heartwire: EMEA issues warning on possible clopidogrel-PPI interaction, but is there really a problem? http://bit.ly/b9M2n
Clopidogrel resistance and compliance
theheart.org — “The idea that clopidogrel nonresponsiveness could actually be due to noncompliance has been suggested.” View full resource at theheart.org
Most Recently Shared on December 7, 2009 at 7:06 pm By:
Clopidogrel resistance: Is it just noncompliance? http://bit.ly/6zTEtp #heartwire
FDA alert on clopidogrel PPI
theheart.org — “The FDA has issued a new warning on an interaction between clopidogrel and the PPI omeprazole and other drugs that inhibit the CYP2C19 enzyme, just weeks after the only randomized trial on this issue reported no such interaction.” View full resource at theheart.org
Most Recently Shared on November 17, 2009 at 9:25 pm By:
Cardiologists shocked by new FDA alert on clopidogrel-PPI interaction http://bit.ly/1c8h4X #SS09 #aha09
Clopidogrel gene and stent thrombosis
theheart.org — “A polymorphism in one of the genes responsible for metabolizing clopidogrel to its active form has been shown to be associated with an increased risk of stent thrombosis in patients undergoing PCI. (Sibbing D et al. Eur Heart J; published online before print February 4, 2009.)” View full resource at theheart.org
Most Recently Shared on February 12, 2009 at 11:36 pm By:
Clopidogrel gene mutation linked to higher rate of stent thrombosis http://tinyurl.com/cxm6jp
Generic clopidogrel in EU
theheart.org — “The European Medicines Agency has given the green light to six generic versions of clopidogrel, which means that the products could be available in a number of European Union countries within a few months.” View full resource at theheart.org
Most Recently Shared on June 2, 2009 at 4:00 pm By:
heartwire: Six generic clopidogrel versions pass first EU marketing hurdle http://bit.ly/1agUYB
Genotyping in US clopidogrel label
theheart.org — “The label has been updated to include additional information on factors affecting patients' responses to the drug, including a new section on pharmacogenetics and advice that concomitant use of drugs that inhibit the CYP2C19 enzyme, such as omeprazole, should be discouraged.” View full resource at theheart.org
Most Recently Shared on May 21, 2009 at 7:44 pm By:
heartwire: Genotyping info now in US clopidogrel label http://bit.ly/t6bBH
Doubling clopidogrel dose in ACS
theheart.org — “UPDATED WITH COMMENTARY // Doubling the loading and maintenance doses of clopidogrel in acute coronary syndrome patients who underwent planned PCI significantly reduces stent thrombosis and cardiovascular events, largely driven by reductions in MI, without a significant increase in major bleeding, report researchers.” View full resource at theheart.org
Most Recently Shared on August 30, 2009 at 3:55 pm By:
heartwire: CURRENT OASIS-7: Benefit to doubling clopidogrel dose in ACS patients undergoing PCI http://bit.ly/12xYSx
Clopidogrel genes and PPI
theheart.org — “The analysis also looked at the effect of PPIs and found that they were associated with an increased risk of events only in high-risk patients.” View full resource at theheart.org
Most Recently Shared on July 5, 2010 at 9:45 pm By:
New meta-analysis: CYP2C19*2 carriers at higher risks of events on clopidogrel: The analysis also looked at the ef... http://bit.ly/d1uIcH
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Shelley Wood
Managing editor for heartwire on theheart.org--the most authoritative, balanced, and insightful cardiovascular disease news online. http://is.gd/nHJ4
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Shelley Wood
Managing editor for heartwire on theheart.org--the most authoritative, balanced, and insightful cardiovascular disease news online. http://is.gd/nHJ4
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Shelley Wood
Managing editor for heartwire on theheart.org--the most authoritative, balanced, and insightful cardiovascular disease news online. http://is.gd/nHJ4
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